Protective effect of Guanxinning on antipsychotic-induced cardiac impairment in long-term hospitalized psychiatric patients

Guanxinning significantly mitigates antipsychotic-induced cardiac injury in psychiatric patients, demonstrating: Normalization of electrophysiological parameters, Preservation of systolic/diastolic function, suppression of oxidative stress and inflammation. These findings support its clinical application as an adjunctive cardioprotective therapy, potentially through inhibition of myocardial apoptosis and antioxidant upregulation.

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Publication Details

Journal
World Journal of Psychiatry
Published
2025-12-31
DOI
https://doi.org/10.5498/wjp.v16.i1.111840
Primary Topic
Cardiac electrophysiology and arrhythmias
Type
article
Field-Weighted Citation Impact
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article

Protective effect of Guanxinning on antipsychotic-induced cardiac impairment in long-term hospitalized psychiatric patients

Junjie Wang, Fugang Luo, Juan Yan, Kai-Jie Fang et al.
World Journal of Psychiatry
Cardiac electrophysiology and arrhythmias
article

Protective effect of Guanxinning on antipsychotic-induced cardiac impairment in long-term hospitalized psychiatric patients

Junjie Wang, Fugang Luo, Juan Yan, Kai-Jie Fang, Wen-Ye Wu, Hai-Dong Song, Hao-Yu Xing
article en

Abstract

Guanxinning significantly mitigates antipsychotic-induced cardiac injury in psychiatric patients, demonstrating: Normalization of electrophysiological parameters, Preservation of systolic/diastolic function, suppression of oxidative stress and inflammation. These findings support its clinical application as an adjunctive cardioprotective therapy, potentially through inhibition of myocardial apoptosis and antioxidant upregulation.

World Journal of PsychiatryVol. 16(1)
Zhejiang Chinese Medical University (CN), Zhejiang Medical and Health Group Hangzhou Hospital (CN), Hangzhou Seventh Peoples Hospital (CN)
Good health and well-being
Openalex Percentile: Top 30%
Cardiac electrophysiology and arrhythmias
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