Comparative diagnostic efficacy of 18F-FDG and FAPI PET/CT in primary liver cancers: A systematic review and meta-analysis

FAPI PET/CT achieved higher sensitivity and diagnostic accuracy than FDG in primary liver cancers, particularly in early-stage and metabolically heterogeneous tumors. FAPI offers transformative potential for clinical use despite its lower specificity in patients with cirrhosis. To optimize integration into diagnostic pathways, standardized protocols and large-scale validation are needed.