Pan‐cancer multi‐omics reveals DCAF7 as an immune‐modulating prognostic driver and Wnt/β‐catenin activator in hepatocellular carcinoma
DCAF7 is up-regulated in various tumours and correlates with poor prognosis, particularly in LIHC. High DCAF7 expression is linked to CD4<sup>+</sup> T cell infiltration, up-regulation of immune checkpoint genes and increased tumour mutational burden, suggesting a role in tumour immune escape. DCAF7 stabilises β-catenin by enhancing GSK-3β Ser9 phosphorylation, thereby driving c-Myc/cyclin D1 expression and contributing to proliferation and migration in LIHC. DCAF7-high tumours demonstrate therapeutic vulnerability to 17-AAG, docetaxel and CDK/GSK-3 inhibitor, revealing potential targeted treatment strategies.
Authors
- Ruina Luan
- X. Lin
- Shiping Luo (ORCID: https://orcid.org/0000-0001-5066-0021)
- Hao Lin (ORCID: https://orcid.org/0000-0003-0062-1061)
- Maohe Chen
- Xin Zhao
- Jianpeng Li
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Cancer Hospital (CN)
- Putian University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1002/ctm2.70572
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00