Segmentectomy versus lobectomy for stage I non-small cell lung cancer: a real-world propensity score-matched analysis

Despite higher recurrence risk, anatomical segmentectomy with radical lymphadenectomy achieved equivalent OS to lobectomy for selected stage I NSCLC ≤2 cm. The relatively small sample size (n=50) limits statistical power, and these findings should be considered exploratory and hypothesis-generating. This parenchyma-sparing approach represents a valuable option in experienced centers, preserving pulmonary function while maintaining oncological adequacy. Careful patient selection and meticulous surgical technique remain paramount for optimal outcomes.