Heterogeneity of antiphospholipid antibody profiles in a clinical cohort and association with distinct clinical features
Distinct antiphospholipid antibody heterogeneity exists, categorisable into 'classical', 'inflammatory' and 'restricted' subtypes. This study identifies aPS/PT-IgM as a strong independent serological marker associated with clinical status. Incorporating aPS/PT-IgM into routine testing could significantly reduce seronegative APS misdiagnosis.
Authors
- Shangjia Jin
- Shuo Yang (ORCID: https://orcid.org/0000-0001-6746-123X)
- Yuying Nie
- H Guo (ORCID: https://orcid.org/0000-0002-3016-6955)
- L G Cui
- Zhongjun Shen
- He Wang
- Qi Liu
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- RMD Open
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/rmdopen-2025-006406
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China