Evaluation of The Topical Effect of Calendula Officinalis Oral Paste in The Treatment of Recurrent Aphthous Stomatitis: A Randomized Double-Blind Controlled Trial

Background and Objectives: Recurrent aphthous stomatitis is the most common recurrent ulceration in the oral mucosa. The anti-inflammatory and wound-healing properties of Calendula officinalis make it a medicinal plant. This study aims to evaluate Calendula Officinalis 10% and 15% oral pastes compared with triamcinolone acetonide 0.1% and placebo oral pastes, and to evaluate salivary Irisin as an inflammatory marker before and after treatment. Materials and Methods: A randomized, double-anonymized case-control clinical study included 60 patients with minor recurrent aphthous stomatitis (age range: 16-50 years. Patients used (Calendula officinalis in 10 % and 15 %, triamcinolone acetonide 0.1 % and placebo) oral pastes for one week. Clinical observation for (ulcer size, pain and erythema) was done on days (0, 4 and 7). Salivary irisin level was measured before and after treatment. Results: Significant differences were noted by topical treatment with 10% and 15% calendula officinalis and triamcinolone acetonide 0.1% oral pastes at the 4th and 7th day in reducing ulcer size, erythema and pain (P<0.001). The most significant reduction was achieved with 15% Calendula officinalis on the 4th day. A significant difference in salivary irisin levels was observed before and after treatment with all four group pastes (P<0.001). Conclusion: Calendula officinalis 15% oral paste showed a significant effect on reducing ulcer size, pain, and erythema in Recurrent Aphthous Stomatitis patients over 4 days. Keywords: Recurrent Aphthous Stomatitis, Calendula Officinalis, Inflammation, Irisin