Pan cohort immune biomarker of CD8 lymphocyte activation enabling HGSOC outcome prediction and treatment response
CIPS captures a CD8<sup>+</sup> T cell activation program that powerfully stratifies late-stage HGSOC, forecasts therapeutic benefit and offers a practicable biomarker for personalized immuno-oncology strategies.
Authors
- Chu Chu (ORCID: https://orcid.org/0000-0002-8151-1157)
- Lijuan Niu (ORCID: https://orcid.org/0000-0003-1286-5020)
- Xiaoyan Yu (ORCID: https://orcid.org/0000-0002-0748-3522)
- Ran Wei
- Nannan Fan
- Liping Qin
- Yunhong Zhang
- Zhen Zhang
- Bin Wang
- Siambi Kikete
- Jiarui Wu
- Xinkui Liu
- Feifei Shi
- Qiaoqiao Han
- Ruohan Wang
- Xia Li
- Zihan Lu
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Kenyatta University (KE)
- Beijing University of Chinese Medicine (CN)
- Shanghai Cancer Institute (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1007/s12672-025-04363-5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00