Spatial proteomics of tertiary lymphoid structures reveals correlation with immunotherapy response in Merkel cell carcinoma
This study demonstrated a significant positive correlation between the number of TLS and ICI response in MCC. Additionally, our results suggest that the immune composition and spatial configuration within TLS may be important determinants of ICI efficacy.
Authors
- Yukiko Kiniwa (ORCID: https://orcid.org/0000-0003-3757-7375)
- MASAHITO YASUDA
- Hideyuki Ishikawa (ORCID: https://orcid.org/0000-0002-6767-1242)
- H. Kato
- Dai Ogata (ORCID: https://orcid.org/0000-0002-1335-7100)
- M. Nakamura
- Yi-Wen Ko
- Y. Nakamura
- Reiko Nakamura
- Shinji Kano
- Akimichi Morita
- Kotaro Nagase
- Jiayue Hu
- Junji Kato
- Takeo Maekawa
- Tetsuya Magara
- Maki Yoshimitsu
Institutions
- JPMorgan Chase & Co (United States) (US)
- Shinshu University (JP)
- Sapporo Medical University (JP)
- Jichi Medical University (JP)
- Gunma University (JP)
- Fukuoka University (JP)
- Nagoya City University (JP)
- National Cancer Centre Japan (JP)
- National Cancer Center (US)
- Shinshu University Hospital (JP)
- Saitama International Medical Center (JP)
- Jichi Medical University Saitama Medical Center (JP)
- Saitama Medical University (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1093/bjd/ljaf525
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00