Advanced Catalysts for Olefin Synthesis: Copper(II) Quinoline-Fused Oxazolidines in Alcohol Dehydration
The new copper(II) catalyst [Cu(<sup>Q</sup>FOX)(CH<sub>3</sub>CN)][OTf]<sub>2</sub> has been synthesized and found to be active for alcohol dehydration to give olefins at 120 °C with a 1% catalyst loading (<sup>Q</sup>FOX = di-2-quinolinyl-fused-oxazolidine). Benzylic, allylic, and tertiary alcohols are all dehydrated. In some cases, ethers are observed to be produced, but these are re-entrained into the catalytic cycle. Unactivated secondary alcohols are also dehydrated. Similar catalysts employing Mn<sup>II</sup>, Fe<sup>II</sup>, Co<sup>II</sup>, and Ni<sup>II</sup> were also synthesized but showed reduced dehydration activity compared to the copper(II) derivative. A Cu<sup>I</sup> analog was also prepared but did not show improved dehydration activity.
Authors
- Ameesh Panda (ORCID: https://orcid.org/0009-0004-3921-4206)
- William D. Jones (ORCID: https://orcid.org/0000-0003-1932-0963)
- William W. Brennessel
- Ruilin Zhang
Institutions
- University of Rochester (US)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1021/acs.joc.5c02669
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00