Fatal Neonatal Echovirus 11 Infection Following Maternal Peripartum Illness: A Case Report with Literature Review

Neonatal Echovirus 11 (E-11) infection acquired perinatally often manifests as a severe, sepsis-like illness with rapid clinical deterioration within the first week of life. The infection is characterized by fulminant multiorgan failure, commonly involving severe hepatitis with coagulopathy, myocarditis, and meningoencephalitis. Adverse outcomes are strongly associated with prematurity and vertical transmission from a mother with an acute peripartum infection, which precludes the transfer of protective serotype-specific antibodies. We present a fatal case of E-11 sepsis in a late preterm neonate following maternal peripartum illness.