AQP9 in Neutrophils Promotes the Formation of NETs by Regulating JAK2-STAT3 Pathway-Mediated Pyroptosis to Aggravate Intestinal Epithelial Cell Injury in Ulcerative Colitis

Knockdown of AQP9 inhibits JAK2-STAT3 pathway-mediated pyroptosis, thereby reducing the formation of NETs and attenuating intestinal epithelial cell injury.

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Publication Details

Journal
Frontiers in Bioscience-Landmark
Published
2025-12-24
DOI
https://doi.org/10.31083/fbl46505
Primary Topic
Inflammasome and immune disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

AQP9 in Neutrophils Promotes the Formation of NETs by Regulating JAK2-STAT3 Pathway-Mediated Pyroptosis to Aggravate Intestinal Epithelial Cell Injury in Ulcerative Colitis

Zetao null Wang, Jianing null Shi, Yao null Sun, Xiaohui null Zhou et al.
Frontiers in Bioscience-Landmark
Inflammasome and immune disorders
article

AQP9 in Neutrophils Promotes the Formation of NETs by Regulating JAK2-STAT3 Pathway-Mediated Pyroptosis to Aggravate Intestinal Epithelial Cell Injury in Ulcerative Colitis

Zetao null Wang, Jianing null Shi, Yao null Sun, Xiaohui null Zhou, Lijun null Shi
article en

Abstract

Knockdown of AQP9 inhibits JAK2-STAT3 pathway-mediated pyroptosis, thereby reducing the formation of NETs and attenuating intestinal epithelial cell injury.

Frontiers in Bioscience-LandmarkVol. 30(12)
Harbin Medical University (CN), Heidelberg University (DE), University Hospital Heidelberg (DE), Shanghai East Hospital (CN), University Medical Centre Mannheim (DE), First Affiliated Hospital of Harbin Medical University (CN)
Good health and well-being
Openalex Percentile: Top 35%
Inflammasome and immune disorders
DOIOpen Access PDFOpenAlex
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AQP9 in Neutrophils Promotes the Formation of NETs by Regulating JAK2-STAT3 Pathway-Mediated Pyroptosis to Aggravate Intestinal Epithelial Cell Injury in Ulcerative Colitis — Zetao null Wang, Jianing null Shi, et al. · Frontiers in Bioscience-Landmark (2025) | TGRS Research Map | TGRS