Trigeminal nerve direct current stimulation modulates raphe–hippocampal network synchrony in rats
TN-DCS dynamically modulates raphe-hippocampal firing and theta synchrony via predominantly amplitude-dependent mechanisms that require intact trigeminal input and serotonergic signaling, supporting its potential as a targeted neuromodulation approach for subcortical circuits involved in cognition and mood.
Authors
- Myles Mc Laughlin (ORCID: https://orcid.org/0000-0001-8574-1841)
- Liyi Chen
- Alireza Majdi
Institutions
- Allen Institute for Brain Science (US)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1016/j.brs.2025.103017
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- China Scholarship Council
- National Institutes of Health