Beyond behavior: neural and cognitive alterations in eating disorders–a systematic review
EDs are underpinned by widespread neural dysregulation involving not only circuits traditionally associated with food intake and reward, but also higher-order large-scale networks supporting cognitive control, interoception, self-referential processing, and emotion regulation. Multimodal neuroimaging studies underscore the necessity for individualized, neurobiologically informed interventions targeting the cognitive control, affect regulation, and reward processing deficits characteristic of EDs. Findings across adolescent and adult samples highlight both state-dependent and potentially developmentally mediated neural alterations, underscoring the relevance of large-scale network connectivity across illness stages.
Authors
- Francesco Monaco (ORCID: https://orcid.org/0000-0002-5617-7943)
- Emanuela Ferrara (ORCID: https://orcid.org/0000-0001-5112-7667)
- Valeria Di Stefano (ORCID: https://orcid.org/0009-0006-2333-0637)
- Martina D’Angelo (ORCID: https://orcid.org/0009-0009-7127-5339)
- Ernesta Panarello (ORCID: https://orcid.org/0009-0002-6270-6490)
- Stefania Landi (ORCID: https://orcid.org/0009-0000-7373-2665)
- Luca Steardo
- Annarita Vignapiano (ORCID: https://orcid.org/0009-0004-8301-3401)
- Benedetta Di Gruttola
- Raffaele Malvone (ORCID: https://orcid.org/0009-0000-5924-6046)
- Stefania Palermo
- Giulio Corrivetti
Institutions
- University of Salerno (IT)
- Magna Graecia University (IT)
- European Biomedical Research Institute of Salerno (IT)
Publication Details
- Journal
- Psychiatry Research Neuroimaging
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1016/j.pscychresns.2025.112132
- Primary Topic
- Eating Disorders and Behaviors
- Type
- article
- Field-Weighted Citation Impact
- 0.00