5MPN effectively targets PFKFB4 and inhibits the glucose metabolism process and invasion of glioblastoma
PFKFB4 shows therapeutic potential as a target for GBM treatment, and its inhibitor 5MPN significantly inhibits glycolysis and invasiveness in GBM. This study provides new insights and potential drug options for targeted therapy in GBM.
Authors
- Zhennan Tao (ORCID: https://orcid.org/0000-0001-7630-2273)
- T. Lu
- Weibang Liang
- Hongbin Ni
- Chen Yu
Institutions
- Nanjing Drum Tower Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.21037/tcr-2025-1740
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00