Exosomal miR-149 from human umbilical cord mesenchymal stem cells attenuates spinal cord injury-induced blood-spinal cord barrier disruption by suppressing the ET-1/PI3K/Akt signaling pathway
hUC-MSC-derived exosomal miR-149 preserves BSCB integrity and promotes functional recovery after SCI by targeting ET-1 and inhibiting the PI3K/Akt pathway, thereby enhancing junctional protein expression. The miR-149/ET-1 axis may represent a promising therapeutic target for SCI.
Authors
- Chenhui Xue (ORCID: https://orcid.org/0000-0001-9160-6822)
- Xiaochen Qiao
- Guan Xiaoming
- Haoyu Feng
- Zhenwu GAO
- Wenxuan Wang
- Hui Wang (ORCID: https://orcid.org/0000-0003-4939-8921)
- Xin Chen
- Xihua Yang
- Lin Sun
- Jiansheng Jing
- Hui Zhang
Institutions
- Hebei Medical University (CN)
- Shanxi Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Shanxi Provincial Cancer Hospital (CN)
- First Hospital of Shanxi Medical University (CN)
- Songjiang District Central Hospital (CN)
- Second Hospital of Shanxi Medical University (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1186/s13287-025-04873-7
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00