Adenosine Acts Through A2AR to Alleviate the Inflammatory Response Caused by Activation of Perivascular-Resident Macrophage-Like Melanocytes
Adenosine attenuates the inflammatory activation of PVM/Ms and enhances their ability to maintain endothelial barrier integrity by binding to A2AR. The findings support adenosine and A2AR as potential therapeutic targets for treating hearing impairments.
Authors
- B Chen
- Zhanjiang null Xu
- Jinhui null Zhang
- Wenya null Fan
- Bin null Zuo
- Jiale null Lv
- Lingling null Neng
Institutions
- Second Affiliated Hospital of Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-12-22
- DOI
- https://doi.org/10.31083/fbl46881
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhengzhou University
- Natural Science Foundation of Henan Province