Molecular insights in HIV-associated cardiac dysfunction
These findings demonstrate dysregulated molecular pathways in cardiomyocytes following exposure to untreated HIV serum versus ART-treated HIV serum from patients followed longitudinally. Altogether, these data suggest that HIV infection and ART contribute to changes seen in the cardiomyocyte phenotype and play complementary roles in the pathogenesis of diastolic dysfunction and HFpEF in PLWH.
Authors
- Markella V. Zanni (ORCID: https://orcid.org/0000-0002-4711-3956)
- Mabel P. Toribio (ORCID: https://orcid.org/0000-0002-4153-5568)
- Suman Srinivasa (ORCID: https://orcid.org/0000-0003-1950-4770)
- David R. Pimentel
- Flora Sam (ORCID: https://orcid.org/0000-0001-8442-9362)
- Eng Leng Saw
- Steven K. Grinspoon
- Adam C. Gower
- María Valero-Muñoz
Institutions
- Boston University (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1038/s43856-025-01349-w
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences