Clostridioides difficile infection in Saudi Arabia: Prevalence, risk factors, and outcomes in a tertiary hospital setting

CDI prevalence reached 10.8% with an 11.4% recurrence rate. Acid-suppressant exposure and combination therapy were key recurrence signals, while metronidazole remains overused despite international guideline shifts. Enhanced antibiotic and acid-suppressant stewardship, alongside improved access to guideline-recommended therapies, are critical to reducing CDI burden in Saudi tertiary hospitals.

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Publication Details

Journal
PLoS ONE
Published
2025-12-31
DOI
https://doi.org/10.1371/journal.pone.0340075
Primary Topic
Clostridium difficile and Clostridium perfringens research
Type
article
Field-Weighted Citation Impact
0.00

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article

Clostridioides difficile infection in Saudi Arabia: Prevalence, risk factors, and outcomes in a tertiary hospital setting

Ahmed Muyidi, Mohammed H. Makkawi, Abdullah M. Aldhaif, Mohammed A. Al-Garni
PLoS ONE
Clostridium difficile and Clostridium perfringens research
article

Clostridioides difficile infection in Saudi Arabia: Prevalence, risk factors, and outcomes in a tertiary hospital setting

Ahmed Muyidi, Mohammed H. Makkawi, Abdullah M. Aldhaif, Mohammed A. Al-Garni
article en

Abstract

CDI prevalence reached 10.8% with an 11.4% recurrence rate. Acid-suppressant exposure and combination therapy were key recurrence signals, while metronidazole remains overused despite international guideline shifts. Enhanced antibiotic and acid-suppressant stewardship, alongside improved access to guideline-recommended therapies, are critical to reducing CDI burden in Saudi tertiary hospitals.

PLoS ONEVol. 20(12)
King Abdulaziz University (SA), King Fahd Medical City (SA), King Abdulaziz Hospital (SA), King Faisal University (SA), King Khalid University (SA)
King Abdulaziz University
Good health and well-being
Openalex Percentile: Top 30%
Clostridium difficile and Clostridium perfringens research
DOIOpen Access PDFOpenAlex
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Clostridioides difficile infection in Saudi Arabia: Prevalence, risk factors, and outcomes in a tertiary hospital setting — Ahmed Muyidi, Mohammed H. Makkawi, et al. · PLoS ONE (2025) | TGRS Research Map | TGRS