French guidelines on systemic treatments for moderate‐to‐severe psoriasis in adults: Update 2025
The current French guidelines for the treatment of psoriasis date from 2019 and do not include the most up-to-date interventions. The Psoriasis Research Group of the French Society of Dermatology has developed new guidelines to provide updated decision-making algorithms for the systemic treatment of adult patients with moderate-to-severe psoriasis. The algorithms were created following a thorough review of existing psoriasis treatment guidelines and recent publications on new systemic therapies not included in previous recommendations. They propose updated treatment strategies that combine established and emerging systemic therapies for patients with plaque psoriasis and psoriatic arthritis. The working group recommends methotrexate, adalimumab or ustekinumab as the primary systemic treatment for patients with psoriasis without symptomatic comorbidities. Additionally, the guidelines include specific recommendations for long-term management in cases of insufficient response or low disease activity, as well as for treating specific types of psoriasis and managing patients with comorbid conditions or those planning a pregnancy.
Authors
- Guillaume Larid
- T. Randriamiarana
- Julie Charles
- Laurie Gouillon (ORCID: https://orcid.org/0000-0003-0254-2420)
- Clarisse Marcombes (ORCID: https://orcid.org/0000-0002-2350-3212)
- Marine Roux (ORCID: https://orcid.org/0000-0002-6447-6601)
- Audrey Melin (ORCID: https://orcid.org/0000-0002-1419-8180)
- Marine Chastagner
- C. Berthault
- É. Sbidian (ORCID: https://orcid.org/0000-0002-1267-5270)
- M. Masson Regnault (ORCID: https://orcid.org/0000-0002-2625-0628)
- H. Aubert
- E. Brenaut (ORCID: https://orcid.org/0000-0002-0170-5083)
- Laëtitia Penso (ORCID: https://orcid.org/0000-0003-1562-0168)
- L. Pina Vegas
- C. Labonne (ORCID: https://orcid.org/0000-0002-3475-0892)
- O. Potié
- Raphaël Ouakrat (ORCID: https://orcid.org/0009-0007-6954-7150)
- J. Gottlieb (ORCID: https://orcid.org/0000-0003-4668-1836)
- Stéphane Mouret (ORCID: https://orcid.org/0000-0003-3880-973X)
- Sandy Sylvain
- Da Hee Pitaud
- Marie‐Emeline Marniquet
- Floriane Etheve
- Lea Canoen
- Colombe Bougeard
Institutions
- Université Paris-Est Créteil (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Communauté urbaine de Lyon (FR)
- Centre Hospitalier de Niort (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Centre d'Investigation Clinique de Nantes (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Centre Hospitalier Régional Universitaire de Brest (FR)
- Polyclinique de Franche Comté (FR)
Publication Details
- Journal
- Journal of the European Academy of Dermatology and Venereology
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1111/jdv.70263
- Citations
- 2
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 1.59