Flow Cytometric Profiling of Peripheral Immune Checkpoints Predicts Prognosis and Reveals PD-1/Treg/IL-10 Crosstalk in B-Cell Lymphoma
Peripheral T-cell ICs, particularly PD-1 and CTLA-4, are significant prognostic biomarkers in B-cell lymphoma. The correlation between PD-1<sup>+</sup> CD4<sup>+</sup> T cells, Treg expansion, and IL-10 elevation is consistent with a mechanism whereby PD-1 signaling may contribute to immunosuppression through Treg differentiation and JAK2/STAT3 pathway activation, providing insights for therapeutic targeting.
Authors
- Bing Pan (ORCID: https://orcid.org/0000-0001-8907-8100)
- Ruyu Ye
- Li Li
- Jie Zhu
- Sijia Li
- Yawei Tang
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/itt.s561672
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00