Upregulation of spondin-2 indicates poorer clinical outcomes and induces radioresistance in gastric cancer
Upregulated SPON2 promotes GC cell proliferation and is associated with poorer OS in patients with GC. SPON2 overexpression induces cellular resistance to radiation, decreasing radiation-induced DNA damage and apoptosis. Therefore, SPON2 may serve as a potential predictor of radiotherapy efficacy and poor prognosis in GC.
Authors
- Yongqin Zhang (ORCID: https://orcid.org/0000-0002-2873-3674)
- Yun Zuo
- Dong Hua
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.21037/tcr-2025-1706
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00