The P2X7 Receptor Promotes Intestinal Fibrosis by Modulating the Gut Microbiota and the Inflammasome
Regulatory mechanisms downstream of P2X7, combined with signals from a dysbiotic microbiota, activate intracellular signaling pathways and the inflammasome, leading to intestinal inflammation and promoting fibrogenesis.
Authors
- Fabiano Lopes Thompson (ORCID: https://orcid.org/0000-0002-7562-1683)
- Camille Victoria Leal (ORCID: https://orcid.org/0000-0002-1175-6896)
- Cristiane Carneiro Thompson (ORCID: https://orcid.org/0000-0001-9510-3675)
- Robson Coutinho‐Silva (ORCID: https://orcid.org/0000-0002-7318-0204)
- Beatriz Elias Ribeiro (ORCID: https://orcid.org/0000-0001-8640-4599)
- Siane Lopes Bittencourt Rosas (ORCID: https://orcid.org/0000-0002-4814-0868)
- Patrícia Teixeira Santana (ORCID: https://orcid.org/0000-0001-7888-5249)
- Heitor Siffert Pereira de Souza
- Gilda Amaral
- Morgana T. Castelo-Branco
- Isadora Schmukler de Lima
- Karen Cristina da Silva e Souza
- Rodrigo Pereira de Oliveira
- João Carlos Machado
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- D’Or Institute for Research and Education (BR)
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101718
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00