Coordinated single-nucleus responses for quantitative disease resistance involve a calcium-associated switch in transcriptional noise

These results provide evidence that stochastic cell-cell variability plays a key role in commitment to plant immunity and in the coordination of plant defense at the organ scale. Our study offers new insights into the mechanisms underlying plasticity and robustness of plant immune responses that can inform the design of strategies to reduce pathogen damage to crops in unstable environments.

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Publication Details

Journal
Genome biology
Published
2025-12-31
DOI
https://doi.org/10.1186/s13059-025-03906-x
Primary Topic
Plant and Biological Electrophysiology Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Coordinated single-nucleus responses for quantitative disease resistance involve a calcium-associated switch in transcriptional noise

Mehdi Khafif, Adelin Barbacci, Matilda Zaffuto, Sylvain Raffaele et al.
Genome biology
Plant and Biological Electrophysiology Studies
article

Coordinated single-nucleus responses for quantitative disease resistance involve a calcium-associated switch in transcriptional noise

Mehdi Khafif, Adelin Barbacci, Matilda Zaffuto, Sylvain Raffaele, Florent Delplace, Tou Cheu Xiong, Darcy A. B. Jones
article en

Abstract

These results provide evidence that stochastic cell-cell variability plays a key role in commitment to plant immunity and in the coordination of plant defense at the organ scale. Our study offers new insights into the mechanisms underlying plasticity and robustness of plant immune responses that can inform the design of strategies to reduce pathogen damage to crops in unstable environments.

Genome biologyVol. 27(1)
Centre National de la Recherche Scientifique (FR), Université de Montpellier (FR), Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR), Institut Agro Montpelier (FR), Services déconcentrés d'appui à la recherche Occitanie-Montpellier (FR), Génétique Physiologie et Systèmes d'Elevage (FR)
Openalex Percentile: Top 23%
Plant and Biological Electrophysiology Studies
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