Epigenetic g predicts cognitive aging and incident dementia in a diverse, nationally representative sample of older adults
Epigenetic g is a scalable, blood-based marker of cognitive function and dementia risk that adds predictive value beyond demographics, socioeconomic indicators, APOE, and neuropathology. Its validation in a diverse, nationally representative U.S. cohort underscores its potential for early risk profiling and for research on social determinants of cognitive aging in cross-national samples.
Authors
- Mateo Farina (ORCID: https://orcid.org/0000-0002-0765-6550)
- Stacey Collins (ORCID: https://orcid.org/0000-0001-7985-1067)
- C. M. Mitchell
- Eric T. Klopack (ORCID: https://orcid.org/0000-0002-0019-1332)
- Jessica D. Faul (ORCID: https://orcid.org/0000-0002-6969-6478)
- Trey Smith
- Eileen Crimmins
Institutions
- University of Southern California (US)
- University of Michigan (US)
- Indiana University Bloomington (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-30
- DOI
- https://doi.org/10.64898/2025.12.23.25342931
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Minnesota