Platelet lipidome alterations in septic shock: a matched case-control study
Septic shock induces significant disruptions in the platelet lipidome, with the extent of these alterations correlating with sepsis-associated thrombocytopenia severity. The observed changes affect multiple lipid classes, surpassing those reported under physiological conditions or in other diseases. These findings highlight the impact of sepsis-driven dysregulated inflammation and coagulopathy on platelet lipid composition, providing new insights into sepsis pathophysiology.
Authors
- Marie Octave
- Hélène Haguet (ORCID: https://orcid.org/0000-0002-3123-5289)
- Caroline Daneault (ORCID: https://orcid.org/0000-0002-9839-7506)
- Laure Morimont (ORCID: https://orcid.org/0000-0001-9195-304X)
- Claudia Tersteeg (ORCID: https://orcid.org/0000-0002-6380-6349)
- Valentine Robaux
- Marc Derive (ORCID: https://orcid.org/0000-0002-8707-5923)
- Laurence Pirotton
- D. Gruson
- Mélanie Dechamps (ORCID: https://orcid.org/0000-0002-0648-1058)
- Julien De Poortere
- Sandrine Horman (ORCID: https://orcid.org/0000-0003-3031-2075)
- van Dievoet Marie-Astrid
- Emma de Cartier d’Yves (ORCID: https://orcid.org/0000-0002-3231-101X)
- Alessandro Campion
- Jonathan Douxfils (ORCID: https://orcid.org/0000-0002-7644-5298)
- Virginie Montiel (ORCID: https://orcid.org/0000-0002-5769-9954)
- Audrey Ginion
- Jérôme Ambroise
- Anik Forest
- Luc Bertrand
- Christophe Beauloye
- Gabriele Muscia
- Christine Des Rosiers
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- University of Namur (BE)
- Montreal Heart Institute (CA)
- Research Institute for Chromatography (BE)
- Université de Montréal (CA)
- UCLouvain (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1016/j.rpth.2025.103332
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00