Delamanid and pretomanid have comparable bactericidal activity but pretomanid potently inhibits <i>Mycobacterium tuberculosis</i> ribosomal rRNA synthesis
We found that delamanid and pretomanid have similar bactericidal activity but pretomanid has superior RS ratio activity. Meaningful differences between drugs within the same class were not captured by conventional CFU-based pharmacodynamics, supporting the value of measuring orthogonal drug effects such as the RS ratio.
Authors
- Gregory T. Robertson (ORCID: https://orcid.org/0000-0001-7157-4034)
- Nicholas D. Walter (ORCID: https://orcid.org/0000-0003-0126-1993)
- Samuel T. Tabor (ORCID: https://orcid.org/0009-0007-3420-8343)
- Emmanuel Musisi (ORCID: https://orcid.org/0000-0001-7229-195X)
- Martin I. Voskuil (ORCID: https://orcid.org/0000-0002-9565-7923)
- Matthew J. Reichlen
- Holly Nielson
- Ashley M Gerwing
- Matthew Zimmerman
- Firat Kaya
Institutions
- Protein Metrics (United States) (US)
- Rocky Mountain MS Center (US)
- Center for Discovery (US)
- University of Colorado Anschutz Medical Campus (US)
- Colorado State University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-30
- DOI
- https://doi.org/10.64898/2025.12.30.697025
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00