Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice
Severe TBI induces transmissible tau<sup>TBI</sup> conformers in humans acutely after injury, potentially exacerbating post-traumatic pathology, and increasing the risk for dementia later in life. ANN NEUROL 2026;99:897-911.
Authors
- Rosaria Pascente (ORCID: https://orcid.org/0000-0002-2264-7898)
- N. Stocchetti
- Ilaria Bertani (ORCID: https://orcid.org/0000-0003-3175-8677)
- Laura Pasetto (ORCID: https://orcid.org/0000-0003-0319-4448)
- Roberto Chiesa (ORCID: https://orcid.org/0000-0002-3842-3733)
- Marco Locatelli (ORCID: https://orcid.org/0000-0001-7138-8653)
- Gloria Vegliante (ORCID: https://orcid.org/0000-0002-7563-0889)
- Fabrizio Ortolano (ORCID: https://orcid.org/0000-0003-1996-948X)
- Eliana Sammali
- Maria Antonietta Chiaravalloti (ORCID: https://orcid.org/0000-0002-5355-1346)
- Serena Scozzari
- Ilaria Lisi (ORCID: https://orcid.org/0000-0003-4092-4112)
- Francesca Pischiutta
- Ilaria Raimondi
- Federico Moro
- David J. Loane
- Carly Douglas
- Elisa R. Zanier
- Valentina Bonetto
- Elena Restelli
Institutions
- University of Milan (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Trinity College (CA)
- Trinity College Dublin (IE)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1002/ana.78132
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- National Institutes of Health