Familial Mediterranean Fever: Perspective and Round on Uncertainties

Introduction: Familial Mediterranean fever (FMF) is a hereditary periodic fever characterized by its autosomal recessive nature. The complexity of its presentation and response to treatment poses significant challenges in diagnosing and managing FMF patients. This article aims to shed light on the primary disagreements concerning FMF diagnosis and management, presenting them in a more accessible format through a simplified flowchart based on existing FMF recommendations. Methods: To conduct this review, we scoured several electronic databases, including PubMed, Google Scholar, and connected papers focusing on FMF recommendations, guidelines, challenges, and conflicting viewpoints. Our search terms included ‘familial Mediterranean fever’ and ‘recommendation’; ‘familial Mediterranean fever’ and ‘guideline’; ‘familial Mediterranean fever’ and ‘update’; ‘familial Mediterranean fever’ and ‘controversies’; ‘familial Mediterranean fever’ and ‘difficulty’. Additionally, we checked the reference lists of relevant journals for further information. Results: To facilitate understanding, we utilized four algorithmic graphics to summarize the recommendations. Conclusion: The diagnosis of FMF patients demands a high level of suspicion, particularly in unusual presentations. By highlighting conflicting points and offering a simplified algorithmic flow chart, physicians can better assess the likelihood of FMF, initiate appropriate treatment, and adjust medication dosages as necessary.