Evaluation of Total Bilirubin in a National Quality Program
EQA results demonstrated temporal variability in bias across all analytical principles, manufacturers, and platforms used for neonatal bilirubin assays. Bias was found to vary with bilirubin concentration. Standardization of neonatal bilirubin assays is urgently needed to ensure more reliable and accurate measurements across different systems. Meanwhile, EQA programs are important in monitoring future assay adjustments to ensure appropriate and consistent management of neonatal hyperbilirubinemia.
Authors
- Miranda van Berkel (ORCID: https://orcid.org/0000-0002-6500-3419)
- Christian V. Hulzebos (ORCID: https://orcid.org/0000-0002-8159-7501)
- Lauren E H Westenberg (ORCID: https://orcid.org/0000-0003-0912-546X)
- Andrei N. Tintu (ORCID: https://orcid.org/0000-0002-5648-1400)
- Marith van Schrojenstein Lantman (ORCID: https://orcid.org/0000-0002-5454-990X)
- Jasper V. Been (ORCID: https://orcid.org/0000-0002-4907-6466)
- Cas Weykamp
- Paul W. Schenk (ORCID: https://orcid.org/0000-0001-8155-9073)
- Eline A.E. van der Hagen (ORCID: https://orcid.org/0009-0008-5769-9832)
- Jolande Vis
- Christian H H Schoenmakers
- Marlies Oostendorp
- Jenny E Kootstra-Ros
- Marieke Frasa
- Marc H M Thelen
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Elkerliek Ziekenhuis (NL)
- Beatrix Kinderziekenhuis (NL)
- Streekziekenhuis Koningin Beatrix (NL)
- Center for Assessment (US)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Rijnstate Hospital (NL)
- Jeroen Bosch Ziekenhuis (NL)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1093/clinchem/hvaf144
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Strong
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Vereniging Trustfonds Erasmus Universiteit Rotterdam
- Ministerie van Binnenlandse Zaken en Koninkrijksrelaties