Association of Arginase-1 Gene and Immunoglobulin E Levels with Asthma Severity in Erbil City Patients

Background and Objectives: Asthma is a chronic respiratory disease that affects the airways and is a major health issue worldwide. We aimed to examine some of these factors. Methods: The arginase-1 gene detected in 50 healthy individuals and 50 in the patients group. Then the level of arginase-1 enzyme examined by using Enzyme-linked immunosorbent assay (ELISA) and immunoglobulin E (IgE) by Cobas e 411. Results: This study found substantial differences in arginase-1 and IgE means between controls and asthmatics. The severe group had the highest mean AGR1 2.35±0.45, whereas the control group had the lowest 0.52±0.27. The severe group had the greatest mean IgE 1285±518.6, whereas the control group had the lowest 53.27±30.45. The arginase gene was found in all participants, but BMI did not affect asthma severity. Conclusions: ARG1 gene found in both patients and healthy people. ARG1 enzyme and IgE significantly associated with the severity of asthma in Erbil city. Keyword: Asthma, arginase-1 gene, IgE, FEV1