Quercetin Modulates Sleep Architecture and Homeostatic Recovery by Inhibiting Neuronal Hyperactivity and Microglial Activation in Mice

These results mechanistically associate the sleep-regulatory effects of quercetin with its dual inhibition of neuronal hyperactivity in sleep-associated brain regions and neuroinflammatory responses. Altogether, this study identifies quercetin as a novel natural modulator of sleep homeostasis, underscoring its therapeutic potential for sleep disorders via anti-excitatory and anti-inflammatory mechanisms.