Macrophage-derived exosomal miR-466i-5p and miR-365-2-5p stimulated by BMP-2 promote osteogenesis

BMP2-activated macrophage-derived exosomes regulate BMSC osteogenic differentiation through miR-466i-5p and miR-365-2-5p, thereby revealing a novel therapeutic target for exosome-based bone regeneration strategies.

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Publication Details

Journal
Journal of Orthopaedic Surgery and Research
Published
2025-12-31
DOI
https://doi.org/10.1186/s13018-025-06563-9
Primary Topic
Extracellular vesicles in disease
Type
article
Field-Weighted Citation Impact
0.00
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article

Macrophage-derived exosomal miR-466i-5p and miR-365-2-5p stimulated by BMP-2 promote osteogenesis

Wanting Li, Yao Yao, Haitao Dong, Na Wang et al.
Journal of Orthopaedic Surgery and Research
Extracellular vesicles in disease
article

Macrophage-derived exosomal miR-466i-5p and miR-365-2-5p stimulated by BMP-2 promote osteogenesis

Wanting Li, Yao Yao, Haitao Dong, Na Wang, Su Chen, Ran Lu
article en

Abstract

BMP2-activated macrophage-derived exosomes regulate BMSC osteogenic differentiation through miR-466i-5p and miR-365-2-5p, thereby revealing a novel therapeutic target for exosome-based bone regeneration strategies.

Journal of Orthopaedic Surgery and ResearchVol. 21(1)
Capital Medical University (CN), Beijing Obstetrics and Gynecology Hospital (CN)
Openalex Percentile: Top 35%
Extracellular vesicles in disease
DOIOpen Access PDFOpenAlex
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