Hypoxia-Activated PERK Promotes Epithelial-Mesenchymal Transition in Gliomas: A Single-Cell and Spatial Transcriptomic Study With Therapeutic Implications
These findings reveal PERK-driven EMT as a key mechanism linking ER stress to glioma progression, with hypoxia reinforcing this axis. Targeting the PERK signaling axis or SPP1-CD44 interactions may offer novel therapeutic strategies against aggressive gliomas.
Authors
- Hong Tang (ORCID: https://orcid.org/0000-0003-4091-0175)
- Jian null Yin
- Xu null Wang
- Jingyan null Gu
- Yaohua null Liu
- Lianping null Gu
- Tingting null Zang
- Yue null Kong
Institutions
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- SAIC-GM (China) (CN)
- Tongren Hospital (CN)
- Stomatology Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-12-17
- DOI
- https://doi.org/10.31083/fbl46692
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00