Inhibition of sphingosine‐1‐phosphate receptor‐2 attenuates chronic gastritis via blocking nuclear translocation of S1P <sub>2</sub> receptors in epithelial cells
Long-term exposure to LPS developed chronic gastritis by stimulating S1P<sub>2</sub> receptors. S1P<sub>2</sub> receptors thus represent a potential target for treatment of chronic gastritis. S1P<sub>2</sub> receptor antagonist blocks the LPS-induced nuclear translocation of S1P<sub>2</sub> receptors, thus attenuating chronic gastritis.
Authors
- Xinda Zhang
- Hui Shao (ORCID: https://orcid.org/0000-0001-7566-6921)
- Shu‐Xiang Cui (ORCID: https://orcid.org/0000-0002-4466-6045)
- Ming Yang (ORCID: https://orcid.org/0000-0002-1617-9960)
- Zejia Sun (ORCID: https://orcid.org/0000-0003-1079-3019)
- Yu‐Yao Cheng
- Xian‐Jun Qu
- Ming‐Yong Tan
- Sheng‐Biao Wan
- Ke‐Qin Li
- Lei‐Lei Jiang
- Cheng‐Wei He
Institutions
- State Grid Corporation of China (China) (CN)
- Capital Medical University (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1111/bph.70323
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Capital Medical University