Humoral and cellular immunogenicity of sequential heterogeneous bivalent SARS-CoV-2 vaccinations in long-term care and retirement home residents
Humoral and cellular immune responses after two heterogenous bivalent vaccines were noninferior to those after a single bivalent vaccine within four months of vaccination. Continued surveillance of vaccine immunogenicity is essential to inform evidence-based decisions on vaccination of vulnerable older adults.
Authors
- Hina Bhakta
- Jessica A. Breznik (ORCID: https://orcid.org/0000-0002-5434-9158)
- Rumi Clare (ORCID: https://orcid.org/0009-0009-5113-706X)
- Jann Catherine Ang
- Allison Kennedy (ORCID: https://orcid.org/0000-0002-0247-0626)
- Lucas Bilaver (ORCID: https://orcid.org/0000-0002-1977-9339)
- Braeden Cowbrough (ORCID: https://orcid.org/0000-0001-5313-5724)
- Jonathan L. Bramson (ORCID: https://orcid.org/0000-0003-2874-6886)
- Ishac Nazy (ORCID: https://orcid.org/0000-0002-5695-4343)
- Andrew P. Costa (ORCID: https://orcid.org/0000-0001-9212-5641)
- Li-Min Liu
- Dawn M.E. Bowdish
- Matthew S. Miller
- Ahmad Rahim
Institutions
- McMaster University Medical Centre (CA)
- Thrombosis and Atherosclerosis Research Institute (CA)
- Impact (CA)
- St. Joseph’s Healthcare Hamilton (CA)
- McMaster University (CA)
Publication Details
- Journal
- Vaccine
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1016/j.vaccine.2025.128160
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00