Exploring the role of Gara Visha in chronic myeloid leukemia: A novel perspective

Chronic Myeloid Leukemia (CML) is a clonal hematological malignancy characterized by the Philadelphia chromosome and constitutive activation of the BCR–ABL1 tyrosine kinase, leading to uncontrolled proliferation of myeloid cells. Despite major therapeutic advances with tyrosine kinase inhibitors and stem cell transplantation, long-term management of CML continues to face challenges related to drug resistance, adverse effects, cost, and incomplete eradication of leukemic stem cells. From an Ayurvedic perspective, chronic exposure to artificial and cumulative toxins described under the concept of Gara Visha represents a comparable pathogenic framework, wherein long-standing toxic influences disrupt metabolism, tissue formation, and systemic balance. This review synthesizes contemporary biomedical literature and classical Ayurvedic texts to explore conceptual parallels between CML pathogenesis and Gara Visha . Available evidence suggests that persistent environmental and chemical exposures leading to genetic instability and leukemogenesis can be viewed through the lens of chronic toxicity described in Ayurveda. Ayurvedic therapeutic principles including Shodhana (detoxification), Shamana (palliative therapy), Rasayana (rejuvenation), and lifestyle regulation offer supportive and integrative strategies aimed at restoring metabolic integrity, enhancing host resilience, and improving quality of life. Integrating modern molecular understanding of CML with Ayurvedic insights provides a broader, systems-oriented perspective and highlights potential avenues for translational research, preventive strategies, and holistic patient-centered care.