To study the demographic and angiographic profiles of coronary artery disease patients in the Bundelkhand region presenting as acute coronary syndrome

Background: Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide, with a rising burden in low-resource regions, such as Bundelkhand. Acute coronary syndrome (ACS), a common presentation of CAD, often manifests with varied demographic and angiographic profiles influenced by regional risk factor patterns. Aims and Objectives: To assess the demographic characteristics, cardiovascular risk factors, and angiographic patterns of CAD in patients presenting with ACS in the Bundelkhand region. Materials and Methods: This cross-sectional observational study included 150 consecutive ACS patients (ST-Elevation Myocardial Infarction [STEMI], Non-STEMI, or unstable angina) admitted to Maharani Laxmi Bai Medical College, Jhansi, from April 2024 to March 2025. Data on demographics, risk factors, and clinical presentation were collected using a structured pro forma. All patients underwent electrocardiogram, cardiac biomarkers, echocardiography, and coronary angiography. Statistical analysis was performed using SPSS v21, with P<0.05 considered significant. Results: Males predominated (80.67%), especially in the 30–50 years group (P=0.04). STEMI was the most common presentation (68.67%), with anterior wall myocardial infarction leading (44.67%). Hypertension (44%), dyslipidemia (41.33%), and diabetes mellitus (30%) were the most frequent risk factors. Angiography revealed single vessel disease (SVD) in 56%, double vessel disease (30%), and triple vessel disease (14%). The left anterior descending (LAD) artery was most involved (28% in SVD). Diabetes and hypertension showed a significant association with multivessel disease (P=0.003 each). Conclusions: ACS in Bundelkhand predominantly affects middle-aged males, with LAD-predominant SVD as the commonest angiographic finding. Diabetes and hypertension significantly influence disease severity, underscoring the need for early detection and aggressive risk factor control.