Aggregation of Platelets and Human <scp>EGFR</scp> Mutant Lung Adenocarcinoma Cells Under Flow Is Governed by Shear Accumulation
These results indicate that platelet-PC-9 aggregation is governed by a shear accumulation-dependent mechanism, optimized under moderate shear and finite exposure, and regulated by P-selectin and CD40L. These findings provide new biophysical insights into transient platelet-PC-9 interactions in circulation and suggest that targeting platelet activation pathways or modulating hemodynamics may prevent hematogenous metastasis.
Authors
- Ying Fang (ORCID: https://orcid.org/0000-0002-2490-8502)
- Jianhua Wu (ORCID: https://orcid.org/0000-0002-1057-7220)
- Xiang Fang (ORCID: https://orcid.org/0009-0006-2908-6532)
- Xiaoxi Sun
- Jiangguo Lin
Institutions
- Guangdong Academy of Medical Sciences (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Microcirculation
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1111/micc.70047
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00