Methylmalonate accumulation contributes to myocardial vulnerability post-reperfusion: a novel therapeutic target and prognostic biomarker
This study revealed an unrecognized harmful effect of MMA on myocardial vulnerability distinct from its isomer succinate. Targeting MMA metabolism represents a promising strategy to optimize risk stratification and mitigate myocardial injury in patients with AMI.
Authors
- Guanpeng Ma (ORCID: https://orcid.org/0000-0002-7390-1454)
- guokun wang (ORCID: https://orcid.org/0000-0002-6085-2358)
- H L Li
- Zhenming Zhang
- Kegong Chen
- J. Guo (ORCID: https://orcid.org/0000-0002-5704-5782)
- Zeng Wang (ORCID: https://orcid.org/0000-0002-3274-4296)
- XiaoXuan Liu
- Shuijie Li
- Haibo Jia
- Yanru Wang (ORCID: https://orcid.org/0000-0001-8272-2450)
- Shanjie Wang
- Shaohong Fang
- Lili Xiu
- Hengxuan Cai
- Bo Yu
- Yan Cui
- Zhaoying Li
Institutions
- Jiamusi University (CN)
- Harbin Medical University (CN)
- Anhui Medical University (CN)
- Guardia Civil (ES)
- First Affiliated Hospital of Jiamusi University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- State Key Laboratory of Chemical Engineering (CN)
- Institute of Zoology (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1186/s12916-025-04596-9
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00