Molecular epidemiology of respiratory syncytial virus in Switzerland 2019–2024 from nucleic acid testing and whole-genome sequencing

By contributing 125 newly assembled RSV genome sequences, we have significantly increased the number of publicly available whole-genome sequences from Switzerland. Our study provides a genomic surveillance of RSV in Switzerland, analysing seasonal patterns, alternating subtype dominance, and consistency with broader European trends. A comprehensive understanding of the molecular epidemiology of RSV enables healthcare providers and public health authorities to monitor the effectiveness of current vaccines and monoclonal antibodies, associate lineages and serotypes with disease severity, implement timely interventions and detect emerging variants, ultimately reducing the burden of RSV-related illnesses.