Pharmacological Inhibition of Pyruvate Dehydrogenase Kinase 4 Enhances Insulin Sensitivity in Mouse Models of Diabetes and Obesity
GM-10395 improves systemic glucose and lipid homeostasis by restoring insulin sensitivity via PDK4 inhibition. These results support GM-10395 as a promising oral therapeutic candidate for insulin resistance in T2DM.
Authors
- Jung-Yi Lee
- Jin Hee Ahn
- Min-Ji Kim
- In-Kyu Lee
- Chae Won Lim
- Bitna Ha
- Ran Ryeong Kim
- Jae-Han Jeon
Institutions
- Kyungpook National University Hospital (KR)
- Kyungpook National University (KR)
- Gwangju Institute of Science and Technology (KR)
Publication Details
- Journal
- Journal of Obesity & Metabolic Syndrome
- Published
- 2025-12-31
- DOI
- https://doi.org/10.7570/jomes25086
- Primary Topic
- Biochemical Acid Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kyungpook National University