Machine learning screening for disulfidptosis genes- associated immunosuppression status in osteosarcoma and rhabdomyosarcoma

Our findings illuminate the landscape of disulfidptosis in OS and RMS, revealing a novel immunosuppressive subtype and a defined five-gene signature for risk stratification. The identification of <i>IQGAP1</i> and the link to macrophages provides new insights for developing targeted therapies and immunotherapeutic strategies for these malignancies.