Single-cell and spatial transcriptome profiling identifies the immunosuppressive spatial niche in <i>KRAS</i> -mutant colorectal cancer
These cellular components collaboratively established an immunosuppressive spatial niche. These findings offer novel theoretical insights and potential targets for the development of immunoregulatory strategies tailored to <i>KRAS</i>-mutant CRC.
Authors
- Sheng Yang (ORCID: https://orcid.org/0009-0006-5815-9307)
- Jiahui Zhou (ORCID: https://orcid.org/0000-0002-3498-1375)
- Zheng Yuan
- Wei Xu (ORCID: https://orcid.org/0000-0001-6774-6366)
- Jianhua Zhu
- Chao Gu (ORCID: https://orcid.org/0000-0002-7128-8721)
- Chenyi Zhong
- Yan Zhang
- Wei Tang
- Xinsheng Miao
- Hao Zuo
- Xinhua Gu
- Yueming Sun
Institutions
- Nanjing Traditional Chinese Medicine Hospital (CN)
- Suzhou Municipal Hospital (CN)
- Changzhou No.2 People's Hospital (CN)
- Changzhou Third People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/jitc-2025-013763
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00