Trends in Plasmodium falciparum resistance markers to sulfadoxine-pyrimethamine and amodiaquine over ten years of seasonal malaria chemoprevention in Moissala Health District, Chad
Surveillance of molecular markers of resistance conducted over a ten-year period in Moissala Health District indicates that SP and AQ remain effective despite prolonged use. However, the rise in quadruple mutants-linked to partial SP resistance-is concerning, and monitoring is needed to detect any increase in quintuple mutants, which confer stronger resistance. These findings underscore the importance of sustained molecular surveillance to guide policy decisions and enable timely adaptations of SMC strategies as resistance patterns evolve.
Authors
- Pascal Ouedraogo
- Mahamat Saleh Issakha Diar (ORCID: https://orcid.org/0000-0001-6160-1393)
- Saschveen Singh (ORCID: https://orcid.org/0000-0002-0432-9298)
- Souleymane Dama (ORCID: https://orcid.org/0000-0002-5191-9207)
- Abdoulaye A. Djimde
- Felix Kouassi
- Jessica Sayyad Hilario
- Francesco Grandesso
Institutions
- University of N'Djamena (TD)
- University of Bamako (ML)
- Epicentre (South Africa) (ZA)
- Université des Sciences, des Techniques et des Technologies de Bamako (ML)
- Médecins Sans Frontières (FR)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1186/s12936-025-05771-2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00