The eNAMPT-Integrin α5β1 Axis Mediates Neutrophil-Endothelial Cell Interactions Driving Inflammation in Ulcerative Colitis
The eNAMPT-integrin α5β1-mediated neutrophil-endothelial communication axis represents a novel pathogenic pathway in UC, providing a foundation for precision therapies targeting this mechanism.
Authors
- Guoshan Chen
- Danzhou Li (ORCID: https://orcid.org/0000-0002-2183-5723)
- Wenbin Song
- Wenhao Xiong
- Feng Qi
- Yongcheng Di
- Wenbin Ji
Institutions
- Tianjin University (CN)
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jir.s554975
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City