Zinner syndrome: Late-Diagnosis in a 55-year-old male and favorable outcome after surgical excision - A case report and review of the literature

Zinner Syndrome (ZS) is a rare congenital anomaly defined by the triad of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ejaculatory duct obstruction. We report a 55-year-old male presenting with chronic perineal pain and LUTS. Imaging confirmed ZS (right renal agenesis, 3.3 × 3.8 cm seminal vesicle cyst). The patient underwent surgical excision, converting from laparoscopic to open due to dense adhesions. He achieved complete symptom resolution and remained stable at two-year follow-up. ZS should be considered in older males with non-specific LUTS. Surgery is effective, and advanced imaging is crucial for diagnosis.

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Journal
Urology Case Reports
Published
2025-12-30
DOI
https://doi.org/10.1016/j.eucr.2025.103332
Primary Topic
Urologic and reproductive health conditions
Type
article
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article

Zinner syndrome: Late-Diagnosis in a 55-year-old male and favorable outcome after surgical excision - A case report and review of the literature

Ryan W. Dobbs, Xuan Thai Ngo, Minh Dinh Nguyen, Kinh Luan Thai et al.
Urology Case Reports
Urologic and reproductive health conditions
article

Zinner syndrome: Late-Diagnosis in a 55-year-old male and favorable outcome after surgical excision - A case report and review of the literature

Ryan W. Dobbs, Xuan Thai Ngo, Minh Dinh Nguyen, Kinh Luan Thai, Duy Dien Nguyen, Tuan Thanh Nguyen, Nho Tinh Le, Quy Van Dinh Le, Do La Quach, Ho Trong Tan Truong
article en

Abstract

Zinner Syndrome (ZS) is a rare congenital anomaly defined by the triad of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ejaculatory duct obstruction. We report a 55-year-old male presenting with chronic perineal pain and LUTS. Imaging confirmed ZS (right renal agenesis, 3.3 × 3.8 cm seminal vesicle cyst). The patient underwent surgical excision, converting from laparoscopic to open due to dense adhesions. He achieved complete symptom resolution and remained stable at two-year follow-up. ZS should be considered in older males with non-specific LUTS. Surgery is effective, and advanced imaging is crucial for diagnosis.

Urology Case ReportsVol. 65
University of California, Irvine (US), Cho Ray Hospital (VN), University of Medicine and Pharmacy at Ho Chi Minh City (VN), Cook County Health and Hospitals System (US)
Good health and well-being
Openalex Percentile: Top 27%
Urologic and reproductive health conditions
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Zinner syndrome: Late-Diagnosis in a 55-year-old male and favorable outcome after surgical excision - A case report and review of the literature — Ryan W. Dobbs, Xuan Thai Ngo, et al. · Urology Case Reports (2025) | TGRS Research Map | TGRS