Serum uric acid levels and longitudinal change in cognitive function in older adults: a sex-stratified population-based study
Low SUA levels were linked to decline in the measure of global cognition and episodic memory among females but not males. High SUA levels were not associated with cognitive decline. Managing SUA levels within the physiological range may support cognitive health, particularly in older females.
Authors
- Amanda J. Rickard (ORCID: https://orcid.org/0009-0001-5774-1219)
- Anne M. Murray (ORCID: https://orcid.org/0000-0002-2787-8433)
- Robyn L. Woods (ORCID: https://orcid.org/0000-0003-1249-6149)
- Md Nazmul Karim
- John J. McNeil (ORCID: https://orcid.org/0000-0002-1049-5129)
- Cammie Tran (ORCID: https://orcid.org/0000-0003-3997-6118)
- Suzanne Gaye Orchard (ORCID: https://orcid.org/0000-0003-0211-3183)
- Catherine Robb (ORCID: https://orcid.org/0000-0001-7586-5533)
- Sheikh Mohammad Alif (ORCID: https://orcid.org/0000-0002-0783-8848)
- Md. Golam Rabbani (ORCID: https://orcid.org/0009-0008-2787-1769)
- Joanne Ryan
- Raj C. Shah
- Zhen Zhou
Institutions
- Rush University Medical Center (US)
- Federation University (AU)
- Berman Center for Outcomes and Clinical Research (US)
- Hennepin Healthcare Research Institute (US)
- Optimal Solutions (United States) (US)
- Monash University (AU)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1093/gerona/glaf296
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Government
- Commonwealth Scientific and Industrial Research Organisation
- Monash University
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- National Cancer Institute