Inositol Requiring Enzyme 1α Mediates Hypertension and Vascular Remodeling
Targeting inositol-requiring enzyme 1α is a potential therapy for hypertension and vascular remodeling by reducing vascular resistance, mitigating intracellular Ca<sup>2+</sup> elevation, and protecting against secretory phenotype in vascular smooth muscle cells.
Authors
- O-Uchi Jin
- Tomoki Hashimoto (ORCID: https://orcid.org/0000-0002-6046-9148)
- Stephanie Cicalese (ORCID: https://orcid.org/0000-0003-1688-5053)
- Yayoi Kimura (ORCID: https://orcid.org/0000-0002-4612-4602)
- Yuki Nakayama (ORCID: https://orcid.org/0000-0001-8620-612X)
- Tomoko Akiyama
- Keisuke Okuno
- Yuka Terada
- Hirotoshi Utsunomiya
- Satoru Eguchi
- Patrick Osei-Owusu
- Keiichi Torimoto
- Brooke Mangano
Institutions
- Barrow Neurological Institute (US)
- University of South Florida (US)
- Yokohama City University Medical Center (JP)
- Osaka Kawasaki Rehabilitation University (JP)
- Case Western Reserve University (US)
- Temple University (US)
- Yokohama City University (JP)
Publication Details
- Journal
- Hypertension
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1161/hypertensionaha.125.26400
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00