Zinner syndrome: Case report and brief review of the literature

Zinner syndrome (ZS) is a rare congenital anomaly of the mesonephric (Wolffian) duct, classically defined by the triad of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ejaculatory duct obstruction. Fewer than 300 cases have been reported in the literature, with most diagnosed in childhood or early adulthood. We present the case of a 17-year-old male who underwent imaging after a syncopal episode, which incidentally revealed inferior vena cava duplication, right renal agenesis, and right-sided cystic dilatation of the seminal vesicle. This case demonstrates radiologic features of ZS and offers a brief review in the embryology, clinical presentation, and management of this syndrome.

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Journal
Radiology Case Reports
Published
2025-12-30
DOI
https://doi.org/10.1016/j.radcr.2025.12.004
Primary Topic
Urologic and reproductive health conditions
Type
article
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article

Zinner syndrome: Case report and brief review of the literature

Eyassu Hailemichael, Cara Lombard, Dhairya A. Lakhani, Kyle R. Knutsen et al.
Radiology Case Reports
Urologic and reproductive health conditions
article

Zinner syndrome: Case report and brief review of the literature

Eyassu Hailemichael, Cara Lombard, Dhairya A. Lakhani, Kyle R. Knutsen, Rita Sico
article en

Abstract

Zinner syndrome (ZS) is a rare congenital anomaly of the mesonephric (Wolffian) duct, classically defined by the triad of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ejaculatory duct obstruction. Fewer than 300 cases have been reported in the literature, with most diagnosed in childhood or early adulthood. We present the case of a 17-year-old male who underwent imaging after a syncopal episode, which incidentally revealed inferior vena cava duplication, right renal agenesis, and right-sided cystic dilatation of the seminal vesicle. This case demonstrates radiologic features of ZS and offers a brief review in the embryology, clinical presentation, and management of this syndrome.

Radiology Case ReportsVol. 21(3)
West Virginia University (US)
Good health and well-being
Openalex Percentile: Top 27%
Urologic and reproductive health conditions
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