Prothrombin conversion accelerates with increasing age in women but not in men: findings from the Moli-sani Cohort Study
The balance between prothrombin conversion and thrombin inactivation becomes more procoagulant with increasing age, but only in women. Therefore, age and gender appropriate reference values for thrombin dynamics parameters would be of interest for the clinical implementation of thrombin generation and thrombin dynamics analysis.
Authors
- Deodato Assanelli (ORCID: https://orcid.org/0000-0002-0286-9493)
- Simona Costanzo (ORCID: https://orcid.org/0000-0003-4569-1186)
- Augusto Filippo Di Castelnuovo (ORCID: https://orcid.org/0000-0001-9767-7998)
- G. Costanzo (ORCID: https://orcid.org/0009-0003-3550-7987)
- Maria Loreto Muñoz Venegas
- Amalia De Curtis (ORCID: https://orcid.org/0000-0001-5104-0318)
- Jos Vermylen
- Concetta Civitillo
- Licia Iacoviello
- Marisa Ninivaggi
- Chiara Cerletti
- Giovanni de Gaetano
- Bas de Laat
- Romy de Laat-Kremers
- Maria Benedetta Donati
- Sara Magnacca
- Emilia Ruggiero
- Teresa Panzera
- Antonietta Pepe
- Anwal Ghulam
- Simona Costanzo
- Alisia Cretella
- Americo Bonanni
- Giovanni de Gaetano
- Francesco Gianfagna
- Francesca Bracone
- Livia Rago
- Renzo Pegoraro
- Amalia De Curtis
- Mariarosaria Persichillo
- Marialaura Bonaccio
- Simona Esposito
- Sabatino Orlandi
- Antonio G. Spagnolo
- Augusto Di Castelnuovo
- Martina Morelli
Institutions
- University of Insubria (IT)
- Istituto Neurologico Mediterraneo (IT)
- Synapse (Netherlands) (NL)
- Ospedale San Giuseppe (IT)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-12-30
- DOI
- https://doi.org/10.1016/j.rpth.2025.103335
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00